실험동물학, 실험동물학실습

• 학사 : 전남대학교 수의과대학 수의학과

• 석사 : 전남대학교 대학원 수의학과

• 박사 : 일본 도쿄대학 대학원 수의학과

• 1999년 4월 –2000년 3월 일본수의사회 초청 수의사연수

• 2000년 4월 –2001년 3월 일본 도쿄대학 대학원 수의학과 연구원

• 2001년 4월 –2005년 3월 일본 신경센터 신경연구소 연구원

• 2005년 4월 – 2005년 9월 일본 신경센터 신경연구소 박사후 연구원

• 2005년 9월 – 전북대학교 수의과대학 수의학과 교수

• 2006년 9월 – 2012년 9월 전북대학교 부설 실험동물센터 센터장

• 2006년 9월 –2012년 9월 전북대학교 동물실험윤리위원회 위원장

• 2012년 11월 – 2014년 10월 전북대학교 수의과대학 부학장

• 2015년 10월 – 현재 (주) 비트윈 대표이사

• 2017년 10월 – 2019년 10월 사단법인 실험동물수의사회 교육인정위원장

• 2019년 10월 – 2021년 10월 사단법인 실험동물수의사회 JCLAM 대사

• 2023년 10월 – 현재 한국실험동물수의사회 부회장

• 2023년 9월 – 2025년 9월 한일연구자협회 부회장

• 2024년 3월 – 현재 한국동물의약품평가원 동물실험윤리위원회 위원장

• 2024년 3월 – 현재 한국식품산업클러스터진흥원 동물실험윤리위원회 위원장

• 2025년 10월 – 현재 한일연구자협회 회장

1. 질환 동물모델 개발 및 평가기술 확립
- 다양한 질환(예: 대사질환, 당뇨병 등)에 대한 전임상 동물모델 구축
- 유효성 및 안전성 평가법 개발

2. 노인성·당뇨병성·비만성 근감소증 연구
- 병태생리 규명 및 치료제·기능성 소재 탐색
- 근육 기능 유지 및 개선을 위한 중재법 개발

3. 건강기능식품 및 기능성 펫푸드 연구
- 인체 대상 건강기능식품의 소재 효능 및 작용기전 연구
- 반려동물 대상 기능성 사료 및 간식 개발 및 평가

4. 세포배양식품(배양육)의 독성 및 알레르기성 평가법 개발
- 배양육의 안전성 확보를 위한 독성 및 면역반응 평가기술 개발
- 규제 대응형 시험법 표준화 연구

• Kwon J, Sekiguchi S, Wang YL, Setsuie R, Yoshikawa Y and Wada K. The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis. Experimental Animal. 2006: 55(1): 35-43.

• Sano Y, Furuta A, Setsuie R, Kikuchi H, Wang YL, Sakurai M, Kwon J, Noda M and Wada K. Photoreceptor cell apoptosis in the retinal degeneration of uchl3-deficient mice. American Journal of Pathology. 2006; 169 (1): 132-141.

• Kwon J. A new approach for the analysis of testicular cells using a Laser Scanning Cytometer. Experimental Animal. 2006: 55(5): 483-486.

• Setsuie R, Wang　YL, Mochizuki H, Osaka H, Hayakawa H, Ichihara N,　Li H, Furuta A, Sato Y, Sun YJ, Kwon J, Kabuta T,　Yoshimi K, Mizuno Y, Aoki S, Noda M, and Wada K. Dopaminergic neuronal cell loss in transgenic mice expressing the Parkinson’s disease–associated UCH-L1 I93M mutant. Neurochemistry International. 2007: 50, 119–129.

• KwonJ, Sekiguchi S, Yoshida E, Hamasaki H, Ichinose S, Hideshima M, Kuraoka M, Takahashi A, Ishii Y, Kyuwa S, Wada K and Yoshikawa Y. Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane block polyspermy. American Journal of Pathology. 2006; 169(5): 1722-1729.

• Kwon J. The new function of two ubiquitin C-terminal hydrolase isozymes as reciprocal modulators of germ cell apoptosis. Experimental Animal. 2007; 56(2): 71-77.

• Shim S, Kwon YB, Yoshikawa Y, Kwon J. Ubiquitin C-Terminal Hydrolase L1 Deficiency Decreases Bone Mineralization. Journal of Veterinary Medical Scinece. 2008: 70 (6), 649-651.

• Shim S, Kim S, Choi DS, Kwon YB, Kwon J. Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction. Food Chem Toxicol. 2012 Mar;50(3-4):597-602.

• Shim S, Kim S, Kwon YB, Kwon J. Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor. Food Chem Toxicol. 2012 Mar;50(3-4):597-602.

• Shim S, Kwon J. Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide. Food Chem Toxicol. 2012 May;50(5):1454-9.

• Song K, Na JY, Oh MH, Kim S, Kim YH, Park BY, Shin GW, Kim B, You M, Kwon J. Synthetic prion Peptide 106-126 resulted in an increase matrix metalloproteinases and inflammatory cytokines from rat astrocytes and microglial cells. Toxicol Res. 2012 Mar;28(1):5-9.

• Kim S, Na JY, Song KB, Choi DS, Kim JH, Kwon YB, Kwon J. Protective Effect of Ginsenoside Rb1 on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes. J Ginseng Res. 2012 Apr;36(2):161-8.

• Na JY, Kim S, Song K, Lim KH, Shin GW, Kim JH, Kim B, Kwon YB, Kwon J. Anti-apoptotic Activity of Ginsenoside Rb1 in Hydrogen Peroxide-treated Chondrocytes: Stabilization of Mitochondria and the Inhibition of Caspase-3. J Ginseng Res. 2012 Jul;36(3):242-247.

• Kim S, Kwon J. COMP-Ang1 inhibits apoptosis as well as improves the attenuated osteogenic differentiation of mesenchymal stem cells induced by advanced glycation end products. Biochim Biophys Acta. 2013 Oct;1830(10):4928-34.

• Kim S, Lee JC, Cho ES, Kwon J. COMP-Ang1 promotes chondrogenic and osteogenic differentiation of multipotent mesenchymal stem cells through the Ang1/Tie2 signaling pathway. J Orthop Res. 2013 Dec;31(12):1920-8.

• Kim S, Lee JC, Cho ES, Kwon J. COMP-Ang1 accelerates chondrocyte maturation by decreasing HO-1 expression. J Cell Biochem. 2013 Nov;114(11):2513-21.

• Kim S, Kwon J. [6]-shogaol attenuates neuronal apoptosis in hydrogen peroxide-treated astrocytes through the up-regulation of neurotrophic factors. Phytother Res. 2013 Dec;27(12):1795-9.

• Song K, Kim S, Na JY, Park JH, Kim JK, Kim JH, Kwon J. Rutin attenuates ethanol-induced neurotoxicity in hippocampal neuronal cells by increasing aldehyde dehydrogenase 2. Food Chem Toxicol. 2014 Oct;72:228-33.

• Na JY, Kim S, Song K, Kwon J. Rutin alleviates prion peptide-induced cell death through inhibiting apoptotic pathway activation in dopaminergic neuronal cells. Cell Mol Neurobiol. 2014 Oct;34(7):1071-9.

• Na JY, Song K, Kim S, Lee HB, Kim JK, Kim JH, Lee JW, Kwon J. Evaluation of porcine xenograft in collateral ligament reconstruction in beagle dogs. Res Vet Sci. 2014 Dec; 97(3):605-610.

• Kim S, Lee D, Kim JK, Kim JH, Park JH, Lee JW, Kwon J. Viscothionin Isolated from Korean Mistletoe Improves Nonalcoholic Fatty Liver Disease via the Activation of Adenosine Monophosphate-Activated Protein Kinase. J Agric Food Chem. 2014 Dec 10;62(49):11876-83.

• Kim S, Kwon J. Thymosin beta 4 improves dermal burn wound healing via downregulation of receptor of advanced glycation end products in db/db mice. Biochim Biophys Acta. 2014 Dec;1840(12):3452-9.

• Kim S, Kwon J. Effect of thymosin beta 4 in the presence of up-regulation of the insulin-like growth factor-1 signaling pathway on high-glucose-exposed vascular endothelial cells. Mol Cell Endocrinol. 2015 Jen; 401: 238-247.

• Kim S, Kwon J. Actin cytoskeletal rearrangement and dysfunction due to activation of the receptor for advanced glycation end products is inhibited by thymosin beta 4. 2005 Apr 15;593(8):1873-1886.

• Na JY, Song K, Kim S, Kwon J. Hepatoprotective effect of phosphatidylcholine against carbon tetrachloride liver damage in mice. Biochem Biophys Res Commun. 2015 May 1;460(2):308-313.

• Song K, Na JY, Kim S, Kwon J. Rutin upregulates neurotrophic factors resulting in attenuation of ethanol-induced oxidative stress in HT22 hippocampal neuronal cells. J Sci Food Agric. 2015 Aug 15; 95(10):2117-2123.

• Kim S, Oh MH, Kim BS, Kim WI, Cho HS, Park BY, Park C, Shin GW, Kwon J. Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells. J Ginseng Res. 2015 Oct;39(4):365-370.

• Kim S, Kwon J. Actin cytoskeletal rearrangement and dysfunction due to activation of the receptor for advanced glycation end products is inhibited by thymosin beta 4. J Physiol. 2015 Apr 15;593(8):1873-86.

• Kim S, Park S, Kim B, Kwon J. Toll-like receptor 7 affects the pathogenesis of non-alcoholic fatty liver disease. Sci Rep. 2016 Jun 9

• Na JY, Song K, Lee JW, Kim S, Kwon J. Pretreatment of 6-shogaol attenuates oxidative stress and inflammation in middle cerebral artery occlusion-induced mice. Eur J Pharmacol. 2016 Oct 5;788:241-247.

• Kim S, Kwon J. Thymosin β4 has a major role in dermal burn wound healing that involves actin cytoskeletal remodelling via heat-shock protein 70. J Tissue Eng Regen Med. 2017 Apr;11(4):1262-1273.

• Na JY, Song K, Lee JW, Kim S, Kwon J. Sortilin-related receptor 1 interacts with amyloid precursor protein and is activated by 6-shogaol, leading to inhibition of the amyloidogenic pathway. Biochem Biophys Res Commun. 2017 Mar 18;484(4):890

• Gu H, Song IB, Han HJ, Lee NY, Cha JY, Son YK, Kwon J Antioxidant Activity of Royal Jelly Hydrolysates Obtained by Enzymatic Treatment. Korean J Food Sci Anim Resour. 2018 Feb;38(1):135-142.

• Gu H, Song IB, Han HJ, Lee NY, Cha JY, Son YK, Kwon J Anti-inflammatory and immune-enhancing effects of enzyme-treade royal jelly. Applied biol Chem 2018. 61(2):27-233.

• Song IB, Gu H, Han HJ, Lee NY, Cha JY, Son YK, Kwon J Omega-7 inhibits inflammation and promotes collgen synthesis through SIRT1 activation. Applied biol Chem 2018. 61(4):433-439.

• Han HJ, Kim S, Kwon J. Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP (106-126)-Treated HT22 Cells. Neurotox Res. 2019 Jul;36(1):58-65.

• Han HJ, Song X, Yadav D, Hwang MS, Lee JH, Lee CH, Kim TH, Lee JJ, Kwon J. Ulmus macrocarpa Hance modulates lipid metabolism in hyperlipidemia via activation of AMPK pathway. PLoS One. 2019 May 23;14(5):e0217112

• Song K, Han HJ, Kim S, Kwon J. Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction. Eur J Pharmacol. 2020 Feb 15;869:

• Song IB, Han HJ, Kwon J.Immune-enhancing effects of gamma-irradiated sericine. Food Science and Biotech 29(7): 969-976.

• SH Ahn, HB Yoon, EJ Jeon, JH Park, J Kwon Viscothionin Suppresses Human Non-small Cell Lung Cancer via Inhibiting the STAT3 Signaling Pathway. European Journal of Medicinal Plants 2020 31(9) 46-53

• EJ Jeon, JH Choi, NY Lee, HJ Oh, HS Kwon, J Kwon Gastroprotective Effects of Fermented Gold Kiwi (Actinidia chinenesis L.) Extracts on HCl/EtOH-Induced Gastric Injury in Rats. Appl. Sci. 2022, 12(10), 5271

• J Choi, I Song, S Lee, M You, J Kwon Protective effects of phosphatidylcholine against hepatic and renal cell injury from advanced glycation end products. Medicina 2022, 58(11), 1519

• JH Choi, S Lee, HJ Han, J Kwon Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H2O2-induced HaCaT Cell Korean J. Physiol. Pharmacol. 2023;27(1):105-112

• S Kim, J Choi, J Kwon Thymosin Beta 4 Protects Hippocampal Neuronal Cells against PrP (106–126) via Neurotrophic Factor Signaling Molecules 2023, 28(9), 3920

• J Choi, S Lee, H Choi, J Lee, N Lee, H Oh, H Kwon, J Kwon Fermented gold kiwi prevents and attenuates chronic alcohol-induced liver injury in mice via suppression of inflammatory responses Appl. Sci. 2023, 13(3), 1877

• J Choi, Y Cho, H Choi, S Lee, H Han, J Lee, J Kwon Thymosin beta 4 inhibits LPS and ATP-induced hepatic stellate cells via the regulation of multiple signaling pathways Int. J. Mol. Sci. 2023, 24(4), 3439

• S Lee, Y Cho, J Choi, H Choi, TS Jung, J Kwon Effects of the Germinated Glycine max and Angelica gigas Nakai Mixture on Hepatic Lipid Metabolism and Bone Turnover Balance in Ovariectomized Rats Appl. Sci. 2023, 13(8), 5084

• J Choi, CH Park, IB Song, S Lee, H Choi, DH Youn, SW Han, JP Jeon, J Kwon Inhibition of Advanced Glycation End Products and NADPH Oxidase by Cirsium japonicum in Streptozotocin-Induced Diabetic Rats Appl. Sci. 2024, 14(6), 2266

• DH Lee, SB Yoon, JS Kim, JW Mo, YJ Jo, J Kwon, SI Lee, J Kwon, CW Park Application of ultrasonographic human estimated foetal weight formulas to cynomolgus monkeys (Macaca fascicularis) at 129–132 days of gestation: A comparative study of estimated and actual birthweight Vet Med Sci. 2024;10:e1521

• DH Lee, JW Mo, SB Yoon, J Kwon, YJ Jo, SI Lee, T Kwon, J Kwon, JS Kim Subcutaneous leiomyosarcoma in a cynomolgus macaque (Macaca fascicularis) Vet Med Sci. 2024;10:e1321

• H Choi, J Choi, Y Jang, YM Lee, MH Kang, HS Kwon, S Kim, J Kwon Anti-Obesity and Antidiabetic Effects of Fig (Ficus carica L.) Fermented Extract Using Lactobacillus plantarum BT-LP-01 Appl. Sci. 2024, 14(15), 6412

• DH Lee, SB Yoon, YJ Jo, JW Mo, J Kwon, SI Lee, J Kwon, JS Kim Comparative analysis of superovulated versus uterine-embryo synchronized recipients for embryo transfer in cynomolgus monkeys (Macaca fascicularis) Front. Vet. Sci. 2024 11:1452631

• J Choi, H Choi, Y Jang, HG Paik, HS Kwon, SM Shin, JS Lee, B Kim, J Kwon Fermented Gold Kiwi Improves Gastrointestinal Motility and Functional Constipation: An Animal Study and Human Randomized Clinical Test Nutrients. 2024 Nov 3;16(21):3778

• J Choi, H Choi, Y Jang, HG Paik, HS Kwon, J Kwon Fermented Gold Kiwifruit Protects Mice Against Non-Alcoholic Fatty Liver Disease in a High-Fat Diet Model Appl. Sci. 2024, 14(24), 11503

• HB Yoon, Y Jang, HG Paik, H Choi, J Choi, J Kwon Effects of Cirsium japonicum var. maackii on avelliation of metabolic disease by improving insulin resistance Laboratory Animal Research 2025 41:3

• I Song, J Song, I Jang, D Noh, C Lee, J Kwon Wrinkle Improvement in HanDam (Twist) on Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice Appl. Sci. 2025, 15(9), 4879

• J Choi, Y Jang, HG Paik, MHJ Ha, J Kwon Gastroprotective Effects of Aqueous Extracts of Broccoli Stems on Acute Injury in Rats: A Comprehensive Evaluation of Gastric Function and Inflammatory Responses Medicina (Kaunas). 2025 Jan 7;61(1):89

저서

• The Proteasome in Neurodegeneration (The gad mouse: a window into UPS-related neurodegeneration and the function of the deubiquitinating enzyme UCH-L1) Springer verlag 2008년 5월


번역

• 실험동물의학 Laboratory Animal Medicine 2nd Edition 한국실험동물의학교수협의회 2009년 2월

• 연구와 교육에 사용되는 산업동물의 동물실험지침 (Guide for the Care and Use of Agricultural Animals in Research and Teaching) ㈜에세이퍼블리싱 2011년 5월

• 실험동물의 관리와 복지 핸드북 (Handbook of Laboratory Animal Management and Welfare) 엠제이엘티디 2011년 5월